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General Guidance: Unlike malaria prophylaxis, doxycycline for STI prevention typically does not require extended use after the trip ends. Studies and clinical guidelines suggest that you should continue doxycycline for up to 1–2 days after your last potential exposure (i.e., after the last sexual activity that may have been high-risk). The reason for this is that doxycycline works best when taken immediately after exposure, preventing the bacteria (such as chlamydia or gonorrhea) from establishing infection.
Duration After Travel: For travelers, the usual recommendation is to take doxycycline during the trip and continue for 1-2 days post-trip. This short window is sufficient, as the window of STI transmission risk is limited to the period when you are actively exposed to potential infection. This is different Unlike malaria, where the parasite could be in the bloodstream for weeks after exposure, bacterial STIs like gonorrhea and chlamydia are most likely to Malariainfect you shortly after exposure.
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